NRP1 – Communicable Diseases Research

Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

SARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경

Article

Published on 2022-12-012022-09-11
Journal: Protein & Cell
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단,

Discovery of natural products to block SARS-CoV-2 S-protein interaction with Neuropilin-1 receptor: A molecular dynamics simulation approach

Article

Published on 2022-09-012022-11-15
Journal: Microbial pathogenesis
[Category] SARS, 유전자 메커니즘, 치료제,

[키워드] addition African Analysis Antiviral compound antiviral target approach binding energy calculate Cell cellular entry characterized Compound conformational database demonstrated disrupt distribution expressed feature functional In-vitro inhibitory effect Interaction mechanism of action molecular molecular dynamic simulation Molecular dynamics simulation multiple organ natural natural product Neuropilin-1 NRP1 performed pleiotropic Protein recent S-protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 research screened selected South stability surface receptor the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic approach viral infectivity virtual screening.
[DOI] 10.1016/j.micpath.2022.105701 PMC 바로가기

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

코로나19 환자 뇌 감염의 형태적, 세포적, 분자적 기초

Article

Published on 2022-08-302022-09-11
Journal: Proceedings of the National Academy of Sciences of
[Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration anxiety symptoms Astrocyte astrocytes biogenesis Brain brain damage Brain infection brain tissue brains cellular changes in characterized Cohort contribute coronavirus cortical Cortical atrophy COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients death deregulated died dysfunction elicit energy metabolism Evidence exhibited fatigue FIVE foci functional genetic material guide histopathological sign histopathological signs Hypothesis impairment in vitro independent individual infect infected individual Infection Interaction manifestation manifested mechanism metabolism metabolite metabolites mild infection molecular basis neural stem cell Neurological symptoms neurological symptoms. neuronal neurons Neuropsychiatric Neurotransmitters NRP1 Patient phenotype Protein reduce Replication SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection Spectrum Support Supporting susceptible syndrome tissue sample viability virus
[DOI] 10.1073/pnas.2200960119 PMC 바로가기 [Article Type] Article

In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols’ Potential for Inhibition of SARS-CoV-2 Internalization

Alchemilla viridiflora Rothm-Polyphenols의 SARS-CoV-2 내재화 억제 가능성에 대한 실리코 및 체외 연구

Article

Published on 2022-08-142022-09-11
Journal: Molecules
[Category] SARS, 변종,

[키워드] ACE2 Alchemilla viridiflora Rothm. angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents binding binding energy binding interaction Compound computational studies Computational study Contact COVID-19 COVID-19 pandemic dose doses E484K effective Effectiveness exhibited flavonoid G476S glycoprotein Health higher affinity highest in silico in vitro inhibited inhibition internalization investigated K417N methanol molecular docking studies Molecular docking study Mutation N439K N501Y neuropilin Neuropilin-1 NRP1 outbreak plants polyphenols Potential Prevent quercetin receptor receptors resulting SARS-CoV-2 SARS-CoV-2 strain selected significantly spike glycoprotein spike glycoprotein. tested V483A virus virus infection Virus spike wild strain
[DOI] 10.3390/molecules27165174 PMC 바로가기 [Article Type] Article

An improved Fuzzy based GWO algorithm for predicting the potential host receptor of COVID-19 infection

Research article

Published on 2022-08-012022-10-05
Journal: Computers in biology and medicine
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 ACE2 protein acute respiratory syndrome ADAM17 Affect affected Algorithm analyzed ASGR1 Asialoglycoprotein Basigin Bone marrow Brain caused CD147 Cell CLEC4M Cluster Clustering Coronavirus-2 COVID-19 COVID-19 infection cytoplasm Differential evolution algorithm disease disintegrin domain drug effective Effectiveness eliminating entry of SARS-CoV-2 enzyme Evolution population dynamics exploratory expresse expression profile EXT1 EXT2 EXT3 Factor fusing Fuzzy clustering G protein-coupled receptor genetic diversity GLCE Glucuronic acid GPR78 Grey Grey wolf optimizer help Host host cell host cell membrane host receptor humans hybridizing I, II identify identifying IHC immunohistochemistry individual Infection inhibiting Interaction intestine kidney KREMEN1 Kringle liver lung mechanism membrane protein Membrane proteins Mutation NDST2 neuropilin NRP1 operator pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 pathogenicity protease Protein PVR receptor replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus serine protease Seurat shown Single cell RNA sequencing data single-cell Spike protein spleen Spread therapeutic target TMPRSS2 toolkit transcriptionally transcriptomics transmembrane protein Transmission virus XYLT1 XYLT2
[DOI] 10.1016/j.compbiomed.2022.106050 [Article Type] Research article

Neuropilin (NRPs) Related Pathological Conditions and Their Modulators

뉴로필린(NRP) 관련 병리학적 상태 및 조절인자

Review

Published on 2022-07-292022-09-11
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 변종,

Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity, and possible drug therapeutics

SARS-CoV-2 Omicron 변이체의 컴퓨터 분석에서 얻은 통찰력: 숙주-병원체 상호작용, 병원성 및 가능한 약물 치료법

Article

Published on 2022-07-012022-09-11
Journal: Immunity, Inflammation and Disease
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 Affect Alter Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach binding affinity Characteristics Comparisons computational analysis correlated correlation correlations COVID-19 COVID-19 case COVID-19 cases docking docking result docking results drug Drug efficacy drugs drugs efficacy effective Effectiveness epidemiological evaluate evaluated Factor genomic sequence Host host-pathogen interaction host-pathogen interaction. human receptors insight Interaction lack less Lopinavir molecular docking molecular dynamics Molecular dynamics simulation Mutation mutational spectrum Nirmatrelvir NRP1 occurred omicron Omicron variant pathogenic pathogenicity Phylogenetic tree protease Protein Proteins raised Receptor-binding domain reconstructed Research response significant difference significant differences tested the receptor-binding domain the SARS-CoV-2 therapeutic approaches variant
[DOI] 10.1002/iid3.639 PMC 바로가기 [Article Type] Article

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

ESCPE-1은 SARS-CoV-2 숙주 인자 Neuropilin-1의 역행 엔도솜 분류를 매개합니다

Article

Published on 2022-06-212022-09-11
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

Going viral in the islet: mediators of SARS-CoV-2 entry beyond ACE2

Review

Published on 2022-06-172023-07-09
Journal: Journal of molecular endocrinology
[Category] COVID19(2023년),

[키워드] ACE2 ADAM17 cathepsin L CD147 COVID-19 diabetes furin GRP78 heparan sulfate islet. NRP1 SARS-CoV-2 TMPRSS2
[DOI] 10.1530/JME-21-0282 PMC 바로가기 [Article Type] Review

Neuropilin-1-Mediated SARS-CoV-2 Infection in Bone Marrow-Derived Macrophages Inhibits Osteoclast Differentiation

골수 유래 대식세포의 뉴로필린-1 매개 SARS-CoV-2 감염은 파골세포 분화를 억제합니다

Article

Published on 2022-05-012022-09-11
Journal: Advanced Biology
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysis angiotensin angiotensin-converting enzyme 2 B.1.351 bone Bone marrow bone marrow-derived macrophages calcium Clinical data Cluster Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients damage dependent on differentiation Evidence expression host cell host cells Human skeleton humans identify impede in vivo Infection inhibit SARS-CoV-2 Interaction investigated knockdown macrophages marrow-derived macrophage metabolism mouse model Mouse models neuropilin Neuropilin-1 neutralization NRP1 organs osteoclast osteoclast differentiation Pathogenesis pathogenesis of SARS-CoV-2 patients phosphorus phosphorus metabolism provide receptor RNA sequencing SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severe acute respiratory syndrome coronavirus 2. significantly Single-cell RNA sequencing susceptible tissue tropism various tissue various tissues virus wild-type
[DOI] 10.1002/adbi.202200007 PMC 바로가기 [Article Type] Article